Production in Monkeys of Complement-fixing Antibodies without Active Immunity by Injection of Killed Plasmodium Knowlesi
نویسندگان
چکیده
Injection into rhesus monkeys of Plasmodium knowlesi killed by heat, formalin, drying, or freezing and thawing stimulates the production of complement-fixing antibodies, but no demonstrable agglutinating or protective antibodies are formed. Possible differences in the immunity mechanisms concerned in active infection and in artificial immunization are discussed.
منابع مشابه
The Soluble Malarial Antigen in the Serum of Monkeys Infected with Plasmodium Knowlesi
When rhesus monkeys with acute Plasmodium knowlesi infection recover after administration of quinine, complement-fixing antibodies are present at maximum titer in the serum soon after the first acute infection has subsided (1), and protective (2) and agglutinating (3) antibodies are demonstrable somewhat later in the course of the chronic disease. Relapses cause an increase in the titer of comp...
متن کاملThe Soluble Malarial Antigen in the Serum of Monkeys Infected with Plasmodium Knowlesi
A soluble malarial antigen which fixes complement with immune serum is found in the serum of monkeys infected with Plasmodium knowlesi. The amount of antigen in the serum is related to the parasite count during the acute phase of the infection. The antigen is not excreted in the urine. Intravenous injection into normal monkeys of serum containing the antigen stimulates the production of specifi...
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In the studies of complement fixation described in this paper, the antigens were prepared from (a) normal monkey red cells, (b) parasitized red cells of monkeys dying with Plasmodium knowlesi infection, (c) the spleens of monkeys dying with Plasmodium knowlesi infection; the sera came from (a) normal human beings, (b) patients with syphilis, (c) patients with paresis who were receiving malaria ...
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متن کاملThe Complement Fixation Reaction in Monkey Malaria
1. A specific complement fixation reaction test for Plasmodium knowlesi malaria in rhesus monkeys is reported with details involved in the preparation of the antigen and procedures employed in setting up the test. 2. It was found that specific complement-fixing antibodies appeared early in the course of the experimental disease and persisted during the course of the chronic infection. 3. The fi...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 70 شماره
صفحات -
تاریخ انتشار 1939